The pharmacometrician's dilemma: the tension between mechanistic and empirical approaches in mathematical modelling and simulation - a continuation of the age-old dispute between rationalism and empiricism?
1 Department of Pharmaceutical Sciences, Center for Data Enabled Science and Engineering State University of New York University at Buffalo, Roswell Park Cancer Institute, Buffalo.
2 Department of Pharmaceutical Sciences, State University of New York University at Buffalo, Buffalo, USA.
3 Otago Pharmacometrics Group, School of Phamacy, University of Otago, Dunedin, New Zealand.