Delayed progression of rabies transmitted by a vampire bat

Arch Virol. 2016 Sep;161(9):2561-6. doi: 10.1007/s00705-016-2927-3. Epub 2016 Jun 15.

Abstract

Here, we compared the growth kinetics, cell-to-cell spread, and virus internalization kinetics in N2a cells of RABV variants isolated from vampire bats (V-3), domestic dogs (V-2) and marmosets (V-M) as well as the clinical symptoms and mortality caused by these variants. The replication rate of V-3 was significantly higher than those of V-2 and V-M. However, the uptake and spread of these RABV variants into N2a cells were inversely proportional. Nevertheless, V-3 had longer incubation and evolution periods. Our results provide evidence that the clinical manifestations of infection with bat RABV variant occur at a later time when compared to what was observed with canine and marmoset rabies virus variants.

Keywords: Bat virus; Dog virus; Marmoset virus; Rabies virus; Replication.

MeSH terms

  • Animals
  • Antigens, Viral
  • Callithrix / virology
  • Cell Line, Tumor
  • Chiroptera / virology*
  • Dogs / virology
  • Mice
  • Rabies / pathology
  • Rabies / veterinary*
  • Rabies / virology
  • Rabies virus / classification
  • Rabies virus / physiology*

Substances

  • Antigens, Viral