YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations

Vera Lyubasyuk; Hong Ouyang; Fa-Xing Yu; Kun-Liang Guan; Kang Zhang

doi:10.4161/23723548.2014.970957

YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations

Mol Cell Oncol. 2014 Dec 1;2(1):e970957. doi: 10.4161/23723548.2014.970957. eCollection 2015 Jan-Mar.

Authors

Vera Lyubasyuk¹, Hong Ouyang¹, Fa-Xing Yu², Kun-Liang Guan², Kang Zhang¹

Affiliations

¹ Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine; University of California; San Diego ; La Jolla, CA USA.
² Department of Pharmacology and Moores Cancer Center; University of California; San Diego ; La Jolla, CA USA.

Abstract

Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells.

Keywords: Yes-associated protein (YAP); guanine nucleotide binding protein (G protein); mutation; uveal melanoma; verteporfin.