Centrosome amplification and cancer: Branching out

Mol Cell Oncol. 2014 Dec 1;2(1):e993252. doi: 10.4161/23723556.2014.993252. eCollection 2015 Jan-Mar.

Abstract

Despite being a common feature of human cancer, the role of supernumerary centrosomes in tumourigenesis is still poorly understood. We have recently described a novel role for centrosome amplification in promoting cell invasion that could impact tumor progression.

Keywords: RAC1; cancer; centrosomes; invasion.