The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy

Xu Feng; Kelei Zhu; Jinghua Liu; Jiang Chen; Jiacheng Tang; Yuelong Liang; Renan Jin; Xiao Liang; Xiujun Cai

doi:10.2147/OTT.S98322

The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy

Onco Targets Ther. 2016 May 30:9:3213-21. doi: 10.2147/OTT.S98322. eCollection 2016.

Authors

Xu Feng¹, Kelei Zhu², Jinghua Liu¹, Jiang Chen¹, Jiacheng Tang³, Yuelong Liang¹, Renan Jin¹, Xiao Liang¹, Xiujun Cai⁴

Affiliations

¹ Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
² Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China; Department of General Surgery, Yinzhou People's Hospital, Ningbo, People's Republic of China.
³ Key Lab of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
⁴ Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China; Key Lab of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

Abstract

Background: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) following hepatectomy using biological markers is of great importance.

Materials and methods: In this study, we collected samples from 54 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of Sema3C and MFN2 in the HCC samples.

Results: Immunohistochemistry results showed that Sema3C and MFN2 co-expression was significantly associated with tumor size. In addition, a significant association between high Sema3C and low MFN2 levels and shorter overall survival was noted, when Sema3C and MFN2 co-expression was analyzed.

Conclusion: The results suggest that the correlative expression level of Sema3C and MFN2 has a strong value in the prognosis of patients with HCC following hepatectomy.

Keywords: MFN2; Sema3C; hepatocellular carcinoma (HCC); prognosis; survival analysis.