Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer

Mohammad Asim; Charlie E Massie; David E Neal

doi:10.1080/23723556.2016.1140262

Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer

Mol Cell Oncol. 2016 Feb 24;3(3):e1140262. doi: 10.1080/23723556.2016.1140262. eCollection 2016 May.

Authors

Mohammad Asim¹, Charlie E Massie¹, David E Neal¹

Affiliation

¹ Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK; Department of Oncology, Addenbrooke's Hospital, CB2 2QQ Cambridge, UK.

Abstract

To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.

Keywords: Androgen Receptor; chaperones; prostate cancer; therapeutic target.