Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting

Hui Li; Kaiming Zhang; Fengmei Pi; Sijin Guo; Luda Shlyakhtenko; Wah Chiu; Dan Shu; Peixuan Guo

doi:10.1002/adma.201601976

Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting

Adv Mater. 2016 Sep;28(34):7501-7. doi: 10.1002/adma.201601976. Epub 2016 Jun 20.

Authors

Hui Li¹, Kaiming Zhang², Fengmei Pi¹, Sijin Guo¹, Luda Shlyakhtenko³, Wah Chiu², Dan Shu¹, Peixuan Guo⁴

Affiliations

¹ College of Pharmacy/Division of Pharmaceutics and Pharmaceutical Chemistry, College of Medicine/Department of Physiology and Cell Biology/Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
² Verna and Marrs McLean Department of Biochemistry and Molecular Biology, National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX, 77030, USA.
³ Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
⁴ College of Pharmacy/Division of Pharmaceutics and Pharmaceutical Chemistry, College of Medicine/Department of Physiology and Cell Biology/Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA. [email protected].

Abstract

RNA tetrahedral nanoparticles with two different sizes are successfully assembled by a one-pot bottom-up approach with high efficiency and thermal stability. The reported design principles can be extended to construct higher-order polyhedral RNA architectures for various applications such as targeted cancer imaging and therapy.

Keywords: Phi29 packaging RNA; RNA nanoparticles; RNA nanotechnology; tetrahedrons; three-way junctions.

Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting

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