Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation

Roberta Caruso; Gabriel Núñez

doi:10.1016/j.cub.2016.05.021

Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation

Curr Biol. 2016 Jun 20;26(12):R508-R511. doi: 10.1016/j.cub.2016.05.021.

Authors

Roberta Caruso¹, Gabriel Núñez²

Affiliations

¹ Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
² Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: [email protected].

PMID: 27326714
DOI: 10.1016/j.cub.2016.05.021

Abstract

NOD1 and NOD2, two members of the intracellular NOD-like receptor family, sense bacterial peptidoglycan-derived fragments and induce pro-inflammatory responses. Recent work provides evidence for a role for NOD1/NOD2 signaling in mediating ER-stress-induced inflammatory responses via a peptidoglycan-independent mechanism.

Publication types

Comment

MeSH terms

Brucella abortus
Endoplasmic Reticulum Stress*
Immunity, Innate*
Inflammation / metabolism*
Nod1 Signaling Adaptor Protein / metabolism*
Nod2 Signaling Adaptor Protein / metabolism*

Substances

Nod1 Signaling Adaptor Protein
Nod2 Signaling Adaptor Protein