Abstract
In the course of our screening program for inhibitors of lipopolysaccharide binding to cellular receptor CD14, a potent inhibitory activity was detected in the cultured broth of Pseudoalteromonas sp. SANK 71903. Four active compounds, ogipeptins A, B, C and D, were isolated from the cultured broth. The structures of these compounds were elucidated by physicochemical data and spectral analyses, and they were determined to be new cyclic lipopeptides.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Lipopeptides / chemistry
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Lipopeptides / isolation & purification*
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Lipopeptides / pharmacology
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Lipopolysaccharide Receptors / metabolism
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Lipopolysaccharides / antagonists & inhibitors*
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Lipopolysaccharides / metabolism
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Spectrum Analysis
Substances
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Anti-Bacterial Agents
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Lipopeptides
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Lipopolysaccharide Receptors
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Lipopolysaccharides
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Peptides, Cyclic