Abstract
Two new tenvermectins, tenvermectins C (1) and D (2), were isolated from Streptomyces avermitilis MHJ1011. Their structures were determined by extensive spectroscopic analysis and by comparison with a related known compound, tenvermectin A. Compounds 1 and 2 exhibited potent nematocidal and acaricidal activities against Bursaphelenchus xylophilus and Tetranychus cinnabarinus.
Keywords:
Streptomyces avermitilis MHJ1011; Tenvermectins C and D; nematocidal and acaricidal activities; structure elucidation.
MeSH terms
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Acaricides / chemistry*
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Acaricides / isolation & purification*
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Acaricides / pharmacology
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Animals
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Antinematodal Agents / chemistry
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Antinematodal Agents / isolation & purification*
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Antinematodal Agents / pharmacology
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Genetic Engineering
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Streptomyces / chemistry*
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Streptomyces / genetics
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Tetranychidae / drug effects
Substances
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Acaricides
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Antinematodal Agents
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Macrolides
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tenvermectin C
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tenvermectin D