InterFeriNg with Acetγlation: Stress-Levels of Acetate Improve Memory T Cell Function

Caroline A Lewis; Matthew G Vander Heiden

doi:10.1016/j.immuni.2016.06.004

InterFeriNg with Acetγlation: Stress-Levels of Acetate Improve Memory T Cell Function

Immunity. 2016 Jun 21;44(6):1243-5. doi: 10.1016/j.immuni.2016.06.004.

Authors

Caroline A Lewis¹, Matthew G Vander Heiden²

Affiliations

¹ The Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Electronic address: [email protected].
² The Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Electronic address: [email protected].

PMID: 27332725
DOI: 10.1016/j.immuni.2016.06.004

Abstract

Catabolic stress can lead to changes in circulating acetate levels. In this issue of Immunity, Balmer et al. (2016) report that serum acetate increases in response to acute infection and describe a mechanism by which this results in acetylation of the glycolytic enzyme GAPDH and improves the recall function of memory CD8(+) T cells.

Publication types

Comment

MeSH terms

Acetates
CD8-Positive T-Lymphocytes / immunology*
Humans
Immunologic Memory / immunology*

Substances

Acetates