A number of clinical cases have been used to demonstrate the possibility of using the myocutaneous flap of the greater pectoral muscle in cervico-maxillo-facial oncological surgery. With this reconstructive possibility, neoplasias judged inoperable up to a short time ago can now be treated surgically, permitting more and more extensive demolition while at the same time guaranteeing first intention healing and acceptable functional and morphological healing. In all cases reported, results were always excellent. It is interesting to note that it was possible, where necessary, to complete and enrich the reconstructive procedure by associating other types of flaps, myocutaneous (deltopectoral) or free (Thiersch).