Neoadjuvant Intraarterial Chemotherapy for Treatment of Malignant Vaginal Tumors in Children: A Single-Center Experience

De-Hua Wu; Min-Ju Li; Da-Xing Tang; Shan Xu; Yong Huang; Jin-Hu Wang; Qiang Shu

doi:10.1016/j.jvir.2016.03.025

Neoadjuvant Intraarterial Chemotherapy for Treatment of Malignant Vaginal Tumors in Children: A Single-Center Experience

J Vasc Interv Radiol. 2016 Jul;27(7):996-1000. doi: 10.1016/j.jvir.2016.03.025.

Authors

De-Hua Wu¹, Min-Ju Li², Da-Xing Tang¹, Shan Xu¹, Yong Huang¹, Jin-Hu Wang³, Qiang Shu⁴

Affiliations

¹ Divisions of Pediatric Urology, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.
² Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China. Electronic address: [email protected].
³ Pediatric Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.
⁴ Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.

PMID: 27338497
DOI: 10.1016/j.jvir.2016.03.025

Abstract

Six patients (aged 3-36 mo) with vaginal tumors (rhabdomyosarcoma and endodermal sinus tumor [EST]; n = 3 each) received intraarterial chemotherapy (IAC) and intravenous chemotherapy. Patients underwent internal iliac artery infusion with cisplatin, pirarubicin, and vindesine. Intravenous chemotherapy with vindesine, ifosfamide, and etoposide was administered after 3 weeks. Vaginal tumors disappeared in all patients after 2 or 3 cycles of alternating therapy. Two patients underwent resection of pelvic metastases. Intravenous consolidation chemotherapy was applied. Four patients were disease-free at a median follow-up of 5.8 years. One patient had pelvic recurrence treated with "salvage" therapy with IAC and surgery and was disease-free for 2.5 years.

Publication types

Observational Study

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Biopsy
Child, Preschool
China
Cisplatin / administration & dosage
Disease-Free Survival
Doxorubicin / administration & dosage
Doxorubicin / analogs & derivatives
Drug Administration Schedule
Endodermal Sinus Tumor / diagnostic imaging
Endodermal Sinus Tumor / drug therapy*
Endodermal Sinus Tumor / secondary
Endodermal Sinus Tumor / surgery
Etoposide / administration & dosage
Female
Humans
Ifosfamide / administration & dosage
Iliac Artery
Infant
Infusions, Intra-Arterial
Infusions, Intravenous
Metastasectomy
Neoadjuvant Therapy*
Pelvic Neoplasms / drug therapy
Pelvic Neoplasms / secondary
Pelvic Neoplasms / surgery
Retrospective Studies
Rhabdomyosarcoma, Embryonal / diagnostic imaging
Rhabdomyosarcoma, Embryonal / drug therapy*
Rhabdomyosarcoma, Embryonal / secondary
Rhabdomyosarcoma, Embryonal / surgery
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Vaginal Neoplasms / diagnostic imaging
Vaginal Neoplasms / drug therapy*
Vaginal Neoplasms / pathology
Vindesine / administration & dosage

Substances

Etoposide
Doxorubicin
pirarubicin
Cisplatin
Vindesine
Ifosfamide