Microenvironmental InterFereNce of metabolism regulates chemosensitivity

Cell Res. 2016 Aug;26(8):867-8. doi: 10.1038/cr.2016.82. Epub 2016 Jun 28.

Abstract

The tumor microenvironment is recognized as a critical regulator of cancer progression, and multiple roles are also emerging for the microenvironment in modulating response to therapeutic intervention. A recent study by Wang and colleagues identified IFN-γ as a central effector of CD8 T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells.

Publication types

  • Comment

MeSH terms

  • Cisplatin
  • Drug Resistance, Neoplasm*
  • Female
  • Glutathione
  • Humans
  • Ovarian Neoplasms*
  • T-Lymphocytes
  • Tumor Microenvironment

Substances

  • Glutathione
  • Cisplatin