Treatment of Benign Prostatic Hyperplasia by Ultrasound-Guided Botulinum Toxin Type A Injection

Cell Biochem Biophys. 2015 Nov;73(2):357-359. doi: 10.1007/s12013-015-0606-8.

Abstract

The objective of the study was to determine the efficacy of ultrasound-guided botulinum toxin type A (BTX-A) injection in the treatment of benign prostatic hyperplasia (BPH). In the 32 patients clinically diagnosed with BPH, 200 IU BTX-A was injected into five points at the lateral and middle lobes of the prostate under the guidance of ultrasound using a balloon dilatational device. The international prostate symptom score, quality of life score, maximum flow rate, post-void residual urine volume, prostate-specific antigen, and prostate volume were determined before treatment and at 1, 3, 6, and 12 months after treatment. All clinical symptoms and indicators were remarkably improved 1 month after the treatment and reached the optimal levels at 6 months post-treatment. This improvement of clinical parameters was maintained for a period of at least 1 year. Ultrasound-guided BTX-A injection was found to be safe and effective in the management of BPH.

Keywords: Benign prostatic hyperplasia; Botulinum toxin type A; Ultrasound-guided therapy.

MeSH terms

  • Aged
  • Botulinum Toxins, Type A / administration & dosage*
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Prostate-Specific Antigen / blood
  • Prostatic Hyperplasia / diagnostic imaging
  • Prostatic Hyperplasia / drug therapy*
  • Quality of Life
  • Treatment Outcome
  • Ultrasonography

Substances

  • Prostate-Specific Antigen
  • Botulinum Toxins, Type A