Expansion of the E138A mutation in newly diagnosed HIV-infected patients in Gran Canaria

Francisco Chamizo; Raúl Gilarranz; Tomás Tosco; Deyanira Carrillo; África Holguín; Évora Santana; Jose Luís Pérez-Arellano; Michele Hernández; Adela Francés; Miguel Ángel Cárdenes; Jose María Zarzalejos; María José Pena-López

doi:10.1016/j.diagmicrobio.2016.06.014

Expansion of the E138A mutation in newly diagnosed HIV-infected patients in Gran Canaria

Diagn Microbiol Infect Dis. 2016 Sep;86(1):58-60. doi: 10.1016/j.diagmicrobio.2016.06.014. Epub 2016 Jun 17.

Affiliations

¹ Microbiology Department, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
² Microbiology Department, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
³ Microbiology Department, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
⁴ Microbiology Department, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
⁵ HIV-1 Molecular Epidemiology Laboratory, Microbiology and Parasitology Department, Hospital Universitario Ramón y Cajal, IRYCIS and CIBERESP, Madrid, Spain. Electronic address: [email protected].
⁶ Microbiology Department, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
⁷ Infectious Diseases Division, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
⁸ Infectious Diseases Division, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
⁹ Infectious Diseases Division, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
¹⁰ Infectious Diseases Division, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
¹¹ Infectious Diseases Division, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].
¹² Microbiology Department, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].

PMID: 27352730
DOI: 10.1016/j.diagmicrobio.2016.06.014

Abstract

Molecular epidemiology allows us to know local HIV transmission and to design strategies of prevention. We studied 25 HIV newly diagnosed patients with the E138A mutation since the year 2010. Most transmission networks involved young and promiscuous men who have sex with men. Recent infection was only documented in patients grouped into the smaller clusters.

Keywords: HIV/AIDS; Phylogenetic analysis; Prevention strategies; Rilpivirine; Transmission networks.

MeSH terms

Adolescent
Adult
Cluster Analysis
Female
HIV / classification*
HIV / enzymology
HIV / genetics*
HIV / isolation & purification
HIV Infections / epidemiology*
HIV Infections / transmission
HIV Infections / virology*
HIV Reverse Transcriptase / genetics*
Humans
Male
Middle Aged
Molecular Epidemiology
Mutation, Missense*
Spain / epidemiology
Young Adult

Substances

HIV Reverse Transcriptase