Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection

Parasitol Int. 2016 Oct;65(5 Pt A):444-6. doi: 10.1016/j.parint.2016.06.009. Epub 2016 Jun 22.

Abstract

Liposomal amphotericin B (LAmb) may fail to heal Leishmania infantum visceral leishmaniasis (VL) in the immunodeficient host. There are currently no guidelines on how to treat such patients and efficacy of miltefosine monotherapy seems limited in this indication. We present 2 cases of patients with VL and AIDS for which LAmb had to be interrupted (one because of toxicity, one because of treatment failure) and who were treated effectively with pentamidine followed by miltefosine.

Keywords: Aids; Liposomal amphotericin B; Miltefosine; Pentamidine; Visceral leishmaniasis.

Publication types

  • Case Reports

MeSH terms

  • Antiprotozoal Agents / therapeutic use*
  • Coinfection / drug therapy
  • HIV Infections / drug therapy*
  • Humans
  • Immunocompromised Host
  • Leishmania infantum / drug effects*
  • Leishmaniasis, Visceral / drug therapy*
  • Leishmaniasis, Visceral / parasitology
  • Pentamidine / therapeutic use*
  • Phosphorylcholine / analogs & derivatives*
  • Phosphorylcholine / therapeutic use

Substances

  • Antiprotozoal Agents
  • Phosphorylcholine
  • miltefosine
  • Pentamidine