Reduction in Clostridium difficile infection associated with the introduction of hydrogen peroxide vapour automated room disinfection

J McCord; M Prewitt; E Dyakova; S Mookerjee; J A Otter

doi:10.1016/j.jhin.2016.05.014

Reduction in Clostridium difficile infection associated with the introduction of hydrogen peroxide vapour automated room disinfection

J Hosp Infect. 2016 Oct;94(2):185-7. doi: 10.1016/j.jhin.2016.05.014. Epub 2016 May 31.

Authors

J McCord¹, M Prewitt², E Dyakova³, S Mookerjee³, J A Otter³

Affiliations

¹ North Mississippi Medical Center, Tupelo, MI, USA. Electronic address: [email protected].
² North Mississippi Medical Center, Tupelo, MI, USA.
³ Imperial College Healthcare NHS Trust, London, UK.

PMID: 27372150
DOI: 10.1016/j.jhin.2016.05.014

Abstract

The clinical impact of implementing hydrogen peroxide vapour (HPV) disinfection of rooms vacated by patients with Clostridium difficile infection (CDI) was evaluated. Breakpoint time series analysis indicated a significant reduction (P<0.001) in the CDI rate at the time when HPV disinfection was implemented, resulting in a reduction in the CDI rate from 1.0 to 0.4 cases per 1000 patient-days in the 24 months before HPV usage compared with the first 24 months of HPV usage. HPV should be considered to augment the terminal disinfection of rooms vacated by patients with CDI.

Keywords: CDI; Clostridium difficile; Decontamination; Disinfection; HPV; Hydrogen peroxide vapour.

MeSH terms

Clostridioides difficile / drug effects*
Clostridioides difficile / isolation & purification
Clostridium Infections / epidemiology
Clostridium Infections / microbiology
Clostridium Infections / prevention & control*
Disease Transmission, Infectious / prevention & control*
Disinfectants / pharmacology*
Disinfection / methods*
Humans
Hydrogen Peroxide / pharmacology*
Patients' Rooms*
Volatilization

Substances

Disinfectants
Hydrogen Peroxide