Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review

Sangeeta Dhami; Ulugbek Nurmatov; Giovanni Battista Pajno; Montserrat Fernandez-Rivas; Antonella Muraro; Graham Roberts; Cezmi Akdis; Montserrat Alvaro-Lozano; Kirsten Beyer; Carsten Bindslev-Jensen; Wesley Burks; George du Toit; Motohiro Ebisawa; Philippe Eigenmann; Edward Knol; Mika Makela; Kari Christine Nadeau; Liam O'Mahony; Nikolaos Papadopoulos; Lars Poulsen; Cansin Sackesen; Hugh Sampson; Alexandra Santos; Ronald van Ree; Frans Timmermans; Aziz Sheikh

doi:10.1186/s13601-016-0113-z

Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review

Clin Transl Allergy. 2016 Jul 5:6:24. doi: 10.1186/s13601-016-0113-z. eCollection 2016.

Authors

Sangeeta Dhami¹, Ulugbek Nurmatov², Giovanni Battista Pajno³, Montserrat Fernandez-Rivas⁴, Antonella Muraro⁵, Graham Roberts⁶, Cezmi Akdis⁷, Montserrat Alvaro-Lozano⁸, Kirsten Beyer⁹, Carsten Bindslev-Jensen¹⁰, Wesley Burks¹¹, George du Toit¹², Motohiro Ebisawa¹³, Philippe Eigenmann¹⁴, Edward Knol¹⁵, Mika Makela¹⁶, Kari Christine Nadeau¹⁷, Liam O'Mahony¹⁸, Nikolaos Papadopoulos¹⁹, Lars Poulsen²⁰, Cansin Sackesen²¹, Hugh Sampson²², Alexandra Santos²³, Ronald van Ree²⁴, Frans Timmermans²⁵, Aziz Sheikh²⁶

Affiliations

¹ Evidence-Based Health Care Ltd, Edinburgh, UK.
² Division of Population Medicine Neuadd Meirionnydd, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.
³ Allergy Unit, Department of Pediatric, University of Messina, Messina, Italy.
⁴ Allergy Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
⁵ Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
⁶ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK ; Faculty of Medicine, University of Southampton, Southampton, UK.
⁷ Swiss Institute for Allergy and Asthma Research, Davos, Switzerland.
⁸ Paediatric Allergy and Clinical Immunology Section, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.
⁹ Pediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany ; Icahn School of Medicine at Mount Sinai, New York, NY USA.
¹⁰ Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.
¹¹ Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
¹² Division of Asthma, Allergy and Lung Biology, Department of Paediatric Allergy, MRC and Asthma Centre in Allergic Mechanisms of Asthma, King's College London and St Thomas NHS Foundation Trust, London, UK.
¹³ Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa Japan.
¹⁴ University Hospitals of Geneva and Medical School, University of Geneva, Geneva, Switzerland.
¹⁵ Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands ; Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁶ Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
¹⁷ Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, Stanford University, Stanford, CA USA.
¹⁸ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
¹⁹ Department of Allergy, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
²⁰ Allergy Clinic, Copenhagen University Hospital, Gentofte, Denmark.
²¹ Koç University Hospital, Istanbul, Turkey.
²² World Allergy Organization (WAO), Milwaukee, WI USA.
²³ Division of Asthma Allergy and Lung Biology, Department of Paediatric Allergy, King's College London/Guy's, and St Thomas' Hospital NHS Foundation Trust, London, UK.
²⁴ Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.
²⁵ Nederlands Anafylaxis Netwerk - European Anaphylaxis Taskforce, Dordrecht, The Netherlands.
²⁶ Allergy and Respiratory Research Group, The University of Edinburgh, Edinburgh, UK.

Abstract

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy.

Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised.

Discussion: The findings from this review will be used to inform the development of recommendations for EAACI's Guidelines on AIT.

Keywords: Allergen immunotherapy; Allergy; Food allergy; Sensitisation; Therapy.

Abstract

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