Efficient and Targeted Suppression of Human Lung Tumor Xenografts in Mice with Methotrexate Sodium Encapsulated in All-Function-in-One Chimeric Polymersomes

Weijing Yang; Yan Zou; Fenghua Meng; Jian Zhang; Ru Cheng; Chao Deng; Zhiyuan Zhong

doi:10.1002/adma.201600065

Efficient and Targeted Suppression of Human Lung Tumor Xenografts in Mice with Methotrexate Sodium Encapsulated in All-Function-in-One Chimeric Polymersomes

Adv Mater. 2016 Oct;28(37):8234-8239. doi: 10.1002/adma.201600065. Epub 2016 Jul 6.

Authors

Weijing Yang¹, Yan Zou¹, Fenghua Meng², Jian Zhang¹, Ru Cheng¹, Chao Deng¹, Zhiyuan Zhong³

Affiliations

¹ Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
² Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China. [email protected].
³ Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China. [email protected].

PMID: 27383234
DOI: 10.1002/adma.201600065

Abstract

Anisamide-functionalized reversibly crosslinked chimeric polymersomes emerge as an "all-function-in-one" nanoplatform for efficient loading and targeted delivery of methotrexate disodium, a potent water-soluble anticancer drug, to sigma receptor overexpressing H460 nonsmall lung cancer xenografts in vivo, leading to markedly improved tumor-growth inhibition and survival rate and depleted adverse effects as compared to the clinically used formulation (Trexall).

Keywords: lung cancer; methotrexate sodium; polymersomes; reduction-sensitive; targeted delivery.

MeSH terms

Animals
Antineoplastic Agents
Cell Line, Tumor
Heterografts
Humans
Lung Neoplasms*
Methotrexate
Mice

Substances

Antineoplastic Agents
Methotrexate