Abstract
We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function.
Keywords:
Anti-inflammatory activity; Curcumin analogues; Free radical scavenging activity; Ischemia/reperfusion injury; Thrombolytic activity.
Published by Elsevier Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / therapeutic use
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Curcumin / analogs & derivatives*
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Curcumin / pharmacology
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Curcumin / therapeutic use
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Cytochromes c / metabolism
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Disease Models, Animal
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Edema / prevention & control
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Enzyme-Linked Immunosorbent Assay
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology*
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Free Radical Scavengers / therapeutic use
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Human Umbilical Vein Endothelial Cells
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Interleukin-6 / blood
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Mice
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Microscopy, Fluorescence
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / pathology
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Oxidative Stress / drug effects
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PC12 Cells
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Quantum Theory
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Rats
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Reactive Oxygen Species / metabolism
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Reperfusion Injury / drug therapy
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Reperfusion Injury / pathology
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Tumor Necrosis Factor-alpha / blood
Substances
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Anti-Inflammatory Agents
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Free Radical Scavengers
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Interleukin-6
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Reactive Oxygen Species
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Tumor Necrosis Factor-alpha
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Cytochromes c
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Curcumin