From the Battlefield to the Bedside: Supporting Warfighter and Civilian Health With the "ART" of Whole Genome Sequencing for Antibiotic Resistance and Outbreak Investigations

Emil Lesho; Xiaoxu Lin; Robert Clifford; Erik Snesrud; Fatma Onmus-Leone; Lakshmi Appalla; Ana Ong; Rosslyn Maybank; Lindsey Nielsen; Yoon Kwak; Mary Hinkle; John Turco; Juan A Marin; Sally Hooks; Stacy Matthews; Stephen Hyland; Jered Little; Paige Waterman; Patrick McGann

doi:10.7205/MILMED-D-15-00197

From the Battlefield to the Bedside: Supporting Warfighter and Civilian Health With the "ART" of Whole Genome Sequencing for Antibiotic Resistance and Outbreak Investigations

Mil Med. 2016 Jul;181(7):621-4. doi: 10.7205/MILMED-D-15-00197.

Authors

Emil Lesho¹, Xiaoxu Lin¹, Robert Clifford¹, Erik Snesrud¹, Fatma Onmus-Leone¹, Lakshmi Appalla¹, Ana Ong¹, Rosslyn Maybank¹, Lindsey Nielsen¹, Yoon Kwak¹, Mary Hinkle¹, John Turco², Juan A Marin², Sally Hooks², Stacy Matthews², Stephen Hyland², Jered Little², Paige Waterman³, Patrick McGann¹

Affiliations

¹ Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910.
² Camp Arifjan, Kuwait, APO, AE 09366.
³ Global Emerging Infections Surveillance, Armed Forces Health Surveillance Center, 1990 Tech Road, Silver Spring, MD 20901.

PMID: 27391613
DOI: 10.7205/MILMED-D-15-00197

Abstract

Awareness, responsiveness, and throughput characterize an approach for enhancing the clinical impact of whole genome sequencing for austere environments and for large geographically dispersed health systems. This Department of Defense approach is informing interagency efforts linking antibiograms of multidrug-resistant organisms to their genome sequences in a public database.

MeSH terms

Biomedical Research / methods*
Disease Outbreaks / prevention & control*
Drug Resistance, Microbial / genetics*
Humans
Warfare
Whole Genome Sequencing / methods*