Radical Smiles Rearrangement: An Update

Molecules. 2016 Jul 6;21(7):878. doi: 10.3390/molecules21070878.

Abstract

Over the decades the Smiles rearrangement and its variants have become essential synthetic tools in modern synthetic organic chemistry. In this mini-review we summarized some very recent results of the radical version of these rearrangements. The selected examples illustrate the synthetic power of this approach, especially if it is incorporated into a domino process, for the preparation of polyfunctionalized complex molecules.

Keywords: Smiles rearrangement; domino reactions; heterocycle; radical cascade; radical chemistry.

Publication types

  • Review

MeSH terms

  • Chemistry Techniques, Synthetic*
  • Chemistry, Organic / methods*