Analyses of the role of the glucocorticoid receptor gene polymorphism (rs41423247) as a potential moderator in the association between childhood overweight, psychopathology, and clinical outcomes in Eating Disorders patients: A 6 years follow up study

Giovanni Castellini; Lorenzo Lelli; Andrea Tedde; Irene Piaceri; Silvia Bagnoli; Ersilia Lucenteforte; Sandro Sorbi; Alessio Maria Monteleone; James J Hudziak; Benedetta Nacmias; Valdo Ricca

doi:10.1016/j.psychres.2016.06.033

Analyses of the role of the glucocorticoid receptor gene polymorphism (rs41423247) as a potential moderator in the association between childhood overweight, psychopathology, and clinical outcomes in Eating Disorders patients: A 6 years follow up study

Psychiatry Res. 2016 Sep 30:243:156-60. doi: 10.1016/j.psychres.2016.06.033. Epub 2016 Jun 25.

Affiliations

¹ Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy; Sexual Medicine and Andrology Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Italy.
² Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
³ Department of Psychiatry, University of Naples SUN, Naples, Italy.
⁴ Vermont Center for Children, Youth, and Families, University of Vermont, Burlington, VT, United States; Erasmus University, Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Child Psychiatry, Washington University, St. Louis, MO, United States.
⁵ Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy. Electronic address: [email protected].

PMID: 27400218
DOI: 10.1016/j.psychres.2016.06.033

Abstract

Childhood overweight and the SNP rs41423247 of the glucocorticoid receptor gene (GR) were reported to represent predisposing factors for Eating Disorders (EDs). The distribution of the polymorphism was evaluated in 202 EDs patients, and in 116 healthy subjects. The Structured Clinical Interview for the DSM-IV and self-reported questionnaires were administered at the admission to the clinic and at 3 time points (end of a cognitive behavioral therapy, 3 and 6 years follow up). G-allele was associated with childhood overweight, depressive disorder comorbidity, and diagnostic instability. G-allele carriers reporting childhood overweight showed greater frequency of subjective binge eating and emotional eating.

Keywords: BclI receptor gene polymorphism; Childhood overweight; Eating Disorders; rs41423247.

MeSH terms

Adult
Cognitive Behavioral Therapy
Diagnostic and Statistical Manual of Mental Disorders
Eating / genetics*
Eating / psychology
Emotions*
Feeding and Eating Disorders / genetics*
Feeding and Eating Disorders / psychology
Feeding and Eating Disorders / therapy
Female
Follow-Up Studies
Humans
Male
Mental Disorders / genetics*
Mental Disorders / psychology
Mental Disorders / therapy
Overweight / genetics*
Overweight / psychology
Polymorphism, Single Nucleotide*
Receptors, Glucocorticoid / genetics*
Surveys and Questionnaires
Treatment Outcome
Young Adult

Substances

Receptors, Glucocorticoid