Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H)

Cancer Cell. 2016 Jul 11;30(1):9-10. doi: 10.1016/j.ccell.2016.06.018.

Abstract

In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3A(R882H)/NRAS(G12D) acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • Epigenomics
  • Leukemia, Myeloid, Acute*
  • Mutation

Substances

  • DNA (Cytosine-5-)-Methyltransferases