An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex

J Res Natl Inst Stand Technol. 2003 Jun 1;108(3):183-91. doi: 10.6028/jres.108.018. Print 2003 May-Jun.

Abstract

This paper describes a test method for measuring the mechanical properties of small, nonlinear membrane samples from a rat model for pulmonary hypertension. The size and nonlinearity of the pulmonary artery samples poses a challenge for developing a test method that will generate quality, reproducible data in the pressure range experienced by the hypertensive pulmonary artery. The experimental method described here has sufficient precision to yield a combined relative standard uncertainty of 4 %. The method is calibrated against 75 µm thick latex and the data agree well with the neo-Hookian model.

Keywords: apparatus; biaxial test; latex; mechanical properties; nonlinear material; pulmonary hypertension; rat pulmonary artery.