Abstract
Two distinct cell populations with lymphoblastic and monocytic characteristics were separated and characterized by multiple cell markers in a patient with terminal transferase-positive acute acute leukemia. The clinical course and sequential cell marker studies were consistent with the interpretation of a defect at the level of a common stem cell giving rise to a terminal transferase--positive lymphoblastic cell population at diagnosis and, following initial therapy, a terminal transferase--negative monocytic population.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Cell Separation
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Female
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Flucytosine / therapeutic use
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Humans
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Leukemia, Lymphoid / blood
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Leukemia, Monocytic, Acute / blood*
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Leukemia, Monocytic, Acute / drug therapy
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Leukemia, Monocytic, Acute / enzymology
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Lymphocytes*
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Monocytes*
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Nucleotidyltransferases / blood*
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Prednisone / therapeutic use
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Thioguanine / therapeutic use
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Vincristine / therapeutic use
Substances
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Vincristine
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Flucytosine
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Nucleotidyltransferases
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Thioguanine
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Prednisone