Opening a Chromatin Gate to Metastasis

John D Minna; Jane E Johnson

doi:10.1016/j.cell.2016.06.031

Opening a Chromatin Gate to Metastasis

Cell. 2016 Jul 14;166(2):275-276. doi: 10.1016/j.cell.2016.06.031.

Authors

John D Minna¹, Jane E Johnson²

Affiliations

¹ Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: [email protected].
² Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: [email protected].

Abstract

What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Line, Tumor*
Chromatin*
Humans
Lung Neoplasms
Neoplasm Metastasis
Small Cell Lung Carcinoma / genetics
Transcription Factors / genetics

Substances

Chromatin
Transcription Factors

Grants and funding

P50 CA070907/CA/NCI NIH HHS/United States