Magnetic resonance imaging based noninvasive measurements of brain hemodynamics in neonates: a review

Pediatr Res. 2016 Nov;80(5):641-650. doi: 10.1038/pr.2016.146. Epub 2016 Jul 19.

Abstract

Perinatal disturbances of brain hemodynamics can have a detrimental effect on the brain's parenchyma with consequently adverse neurodevelopmental outcome. Noninvasive, reliable tools to evaluate the neonate's brain hemodynamics are scarce. Advances in magnetic resonance imaging have provided new methods to noninvasively assess brain hemodynamics. More recently these methods have made their transition to the neonatal population. The aim of this review is twofold. Firstly, to describe these newly available noninvasive methods to investigate brain hemodynamics in neonates. Secondly, to discuss the results that were obtained with these techniques, identifying both potential clinical applications as well as gaps of knowledge.

Publication types

  • Review

MeSH terms

  • Brain / diagnostic imaging*
  • Brain / physiopathology*
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / pathology
  • Cerebrovascular Circulation
  • Hemodynamics*
  • Humans
  • Hypoxia / diagnostic imaging
  • Hypoxia / pathology
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy*
  • Multimodal Imaging
  • Neurodevelopmental Disorders / diagnostic imaging
  • Neurodevelopmental Disorders / pathology
  • Oxygen / chemistry

Substances

  • Oxygen