Imaging and pathological features of gastric lesion of immunoglobulin G4-related disease: A case report and review of the recent literature

Mod Rheumatol. 2019 Mar;29(2):377-382. doi: 10.1080/14397595.2016.1209819. Epub 2016 Jul 21.

Abstract

We describe a 67-year-old man with immunoglobulin G4-related disease (IgG4-RD) presenting with optic neuropathy, dacryoadenitis, periaortitis, retroperitoneal fibrosis, and a gastric mass-like lesion. A mass-like lesion measuring 52 × 40 mm in the antrum of the stomach was found incidentally through whole-body screening for other organ involvement of IgG4-RD using contrast-enhanced computed tomography (CT). Histology of the stomach revealed that the lesion was also IgG4-related and was located in the submucosal layer extending to the subserosal region. This case suggests that the stomach can also be a site of involvement of IgG4-RD.

Keywords: Gastrointestinal lesions; IgG4; Imaging examinations.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Endoscopy, Gastrointestinal / methods
  • Endosonography / methods
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G4-Related Disease / diagnosis*
  • Immunoglobulin G4-Related Disease / immunology
  • Immunologic Tests
  • Incidental Findings
  • Magnetic Resonance Imaging / methods
  • Male
  • Retroperitoneal Fibrosis
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / pathology
  • Tomography, X-Ray Computed / methods

Substances

  • Immunoglobulin G