[Dosing regimens of antibiotics in neonates: Variations in clinical practice and what should be done?]

S Leroux; W Zhao; V Biran; E Jacqz-Aigrain

doi:10.1016/j.arcped.2016.06.002

[Dosing regimens of antibiotics in neonates: Variations in clinical practice and what should be done?]

Arch Pediatr. 2016 Sep;23(9):966-73. doi: 10.1016/j.arcped.2016.06.002. Epub 2016 Jul 19.

[Article in French]

Authors

S Leroux¹, W Zhao², V Biran³, E Jacqz-Aigrain⁴

Affiliations

¹ Service de pharmacologie pédiatrique et pharmacogénétique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France; EA7323, université Paris Diderot, université Paris Descartes, 75019 Paris, France; Service de néonatologie et réanimation néonatale, CHU, hôpital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex, France.
² Service de pharmacologie pédiatrique et pharmacogénétique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France; EA7323, université Paris Diderot, université Paris Descartes, 75019 Paris, France; Centre d'investigation clinique CIC9202, Inserm, 75019 Paris, France.
³ EA7323, université Paris Diderot, université Paris Descartes, 75019 Paris, France; Service de néonatologie et réanimation néonatale, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France.
⁴ Service de pharmacologie pédiatrique et pharmacogénétique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France; EA7323, université Paris Diderot, université Paris Descartes, 75019 Paris, France; Centre d'investigation clinique CIC9202, Inserm, 75019 Paris, France. Electronic address: [email protected].

PMID: 27451383
DOI: 10.1016/j.arcped.2016.06.002

Abstract

There is wide variation in neonatal dosages of antibiotics in clinical practice, both nationally and internationally. This reflects the lack of evaluation of drugs in this therapeutic class, although widely prescribed. Given this situation, optimization of antibiotic prescription is required to ensure efficacy and safety of neonatal treatment and reduce microbial resistance. Rational prescription should be based on the knowledge of developmental pharmacokinetics and pharmacodynamics. Rigorous studies, conducted in collaboration between neonatologists and pharmacologists, are essential to develop and validate evidence-based neonatal dosage regimens.

MeSH terms

Anti-Bacterial Agents / administration & dosage*
Anti-Bacterial Agents / pharmacokinetics
Dose-Response Relationship, Drug
Humans
Infant, Newborn
Reference Books, Medical

Substances

Anti-Bacterial Agents