Endolymphatic Sac Tumor Showing Increased Activity on 68Ga DOTATATE PET/CT

Clin Nucl Med. 2016 Oct;41(10):783-4. doi: 10.1097/RLU.0000000000001315.

Abstract

Endolymphatic sac tumors (ELSTs) are rare tumors arising from the epithelium of the endolymphatic sac and duct that can be either sporadic or associated with von Hippel-Lindau (VHL) disease. We report a case of a VHL patient with histologically proven residual ELST who underwent Ga DOTATATE PET/CT showing increased activity (SUVmax, 6.29) by the ELST. The presented case of a VHL-associated ELST with increased Ga DOTATATE uptake indicates cell-surface expression of somatostatin receptors by this tumor, suggesting the potential application of somatostatin receptor imaging using Ga DOTA-conjugated peptides in the workup and management of these patients.

Publication types

  • Case Reports

MeSH terms

  • Ear Neoplasms / complications
  • Ear Neoplasms / diagnostic imaging*
  • Endolymphatic Sac / diagnostic imaging*
  • Humans
  • Male
  • Middle Aged
  • Organometallic Compounds
  • Positron Emission Tomography Computed Tomography*
  • Radiopharmaceuticals
  • von Hippel-Lindau Disease / complications
  • von Hippel-Lindau Disease / diagnostic imaging*

Substances

  • Organometallic Compounds
  • Radiopharmaceuticals
  • gallium Ga 68 dotatate