Abstract
The Hippo pathway is a key regulator of organ size that has also been implicated in tumorigenesis. Yap, one of the effectors of Hippo signalling, is now reported to support these functions by promoting glutamine synthesis.
MeSH terms
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Animals
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Carcinogenesis / genetics*
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Glutamine / metabolism
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Hippo Signaling Pathway
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Humans
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Liver / metabolism*
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Organ Size / genetics
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Organ Size / physiology
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Protein Serine-Threonine Kinases / metabolism
Substances
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Glutamine
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Protein Serine-Threonine Kinases