Chromosome 14 Abnormality with a Breakpoint of p12 in Adult T-cell Leukemia

K Itoh; N Oku; H Gotoh; T Inaba; S Murakami; N Oku; N Takeda; Y Ura; C Shimazaki; S Nakanishi; H Haruyama; M Nakagawa; N Fujita; M Taniwaki

doi:10.3109/10428199109070292

Chromosome 14 Abnormality with a Breakpoint of p12 in Adult T-cell Leukemia

Leuk Lymphoma. 1991;3(5-6):447-50. doi: 10.3109/10428199109070292.

Authors

K Itoh¹, N Oku¹, H Gotoh¹, T Inaba¹, S Murakami¹, N Oku¹, N Takeda¹, Y Ura¹, C Shimazaki¹, S Nakanishi¹, H Haruyama¹, M Nakagawa¹, N Fujita², M Taniwaki³

Affiliations

¹ a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
² b Department of Laboratory Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
³ c Third Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.

PMID: 27467439
DOI: 10.3109/10428199109070292

Abstract

We describe a patient with adult T-cell leukemia (ATL) with a 14p chromosomal abnormality. Cytogenetic study revealed two clonal populations of leukemic cells in the peripheral blood sample. Both clones were karyotypically related to each other. One of them showed rearrangement of chromosome 14 at break band p 12 (14p12) in addition to + 3, + 7, -X and del(6) (q14q21). The nucleolar organizer region (NOR) is assigned to the band 14p12 and the role of the rearrangement of chromosome 14p12 in the pathogenesis of ATL is discussed.

Keywords: 14p12; Adult T-cell leukemia; Breakpoint; Chromosome abnormality; Nucleolar organizer region.