Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8(+) T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.
Keywords: Adoptive cell transfer; colorectal cancer; frameshift mutation; immunotherapy; microsatellite instablility; neoantigen; neopeptide; tumor-specific CD8+ T cell.