RIFM fragrance ingredient safety assessment, 2-methylundecanol, CAS Registry Number 10522-26-6

Food Chem Toxicol. 2016 Nov:97S:S119-S128. doi: 10.1016/j.fct.2016.07.028. Epub 2016 Jul 27.

Abstract

This material was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analogs 2-butyloctan-1-ol (CAS # 3913-02-8) and 2-ethyl-1-hexanol (CAS # 104-76-7) show that this material is not genotoxic nor does it have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The repeated dose toxicity endpoint was completed using 2-ethyl-1-hexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental toxicity endpoint was completed using 2-ethyl-1-hexanol (CAS # 104-76-7) as a suitable read across analog, which provided a MOE > 100 The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Keywords: Developmental and reproductive toxicity; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Skin sensitization.

Publication types

  • Review

MeSH terms

  • Animals
  • Consumer Product Safety
  • DNA Damage / drug effects
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Endpoint Determination
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / toxicity*
  • No-Observed-Adverse-Effect Level
  • Perfume / chemistry
  • Perfume / toxicity*
  • Rats
  • Risk Assessment
  • Toxicity Tests / methods*

Substances

  • 2-methylundecanol
  • Fatty Alcohols
  • Perfume