Abstract
Polyketides and nonribosomal peptides are two important types of natural products that are produced by many species of bacteria and fungi but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the canal-associated neurons (CANs) and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Products / chemistry
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Biological Products / metabolism
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Biological Products / pharmacology
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Caenorhabditis elegans / cytology
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Caenorhabditis elegans / drug effects
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Caenorhabditis elegans / growth & development*
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Caenorhabditis elegans / metabolism*
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Larva / drug effects
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Larva / growth & development*
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Neurons / metabolism
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Peptides / chemistry
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Peptides / metabolism*
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Peptides / pharmacology
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Polyketides / chemistry
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Polyketides / metabolism*
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Polyketides / pharmacology
Substances
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Biological Products
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Peptides
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Polyketides
Associated data
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PubChem-Substance/315659312
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PubChem-Substance/315659313
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PubChem-Substance/315659314
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PubChem-Substance/315659315
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PubChem-Substance/315659316