Idebenone Maintains Survival of Mutant Myocilin Cells by Inhibiting Apoptosis

Chin Med J (Engl). 2016 Aug 20;129(16):2001-4. doi: 10.4103/0366-6999.187856.
No abstract available

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / genetics
  • COS Cells
  • Chlorocebus aethiops
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism*
  • Eye Proteins / genetics
  • Eye Proteins / metabolism*
  • Glaucoma, Open-Angle / genetics
  • Glaucoma, Open-Angle / metabolism*
  • Glycoproteins / genetics
  • Glycoproteins / metabolism*
  • Humans
  • Mutation
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology

Substances

  • Cytoskeletal Proteins
  • Eye Proteins
  • Glycoproteins
  • trabecular meshwork-induced glucocorticoid response protein
  • Ubiquinone
  • idebenone