Emergence of ileS2-Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis

Pak-Leung Ho; Melissa Chun-Jiao Liu; Kin-Hung Chow; Cindy Wing-Sze Tse; Wai-U Lo; Siu-Ka Mak; Wai-Kei Lo

doi:10.1128/AAC.00948-16

Emergence of ileS2-Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6411-4. doi: 10.1128/AAC.00948-16. Print 2016 Oct.

Authors

Pak-Leung Ho¹, Melissa Chun-Jiao Liu², Kin-Hung Chow², Cindy Wing-Sze Tse³, Wai-U Lo², Siu-Ka Mak⁴, Wai-Kei Lo⁵

Affiliations

¹ Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China [email protected].
² Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
³ Department of Clinical Pathology, Kwong Wah Hospital, Hong Kong Special Administrative Region, People's Republic of China.
⁴ Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong Special Administrative Region, People's Republic of China.
⁵ Department of Medicine, Tung Wah Hospital, Hong Kong Special Administrative Region, People's Republic of China.

Abstract

Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance, Multiple, Bacterial / drug effects
Drug Resistance, Multiple, Bacterial / genetics*
Genes, Bacterial*
Hong Kong
Humans
Methicillin Resistance / genetics
Microbial Sensitivity Tests
Mupirocin / pharmacology
Mupirocin / therapeutic use
Mutation
Plasmids
Staphylococcus lugdunensis / drug effects*
Staphylococcus lugdunensis / genetics*
Staphylococcus lugdunensis / isolation & purification

Substances

Mupirocin

Grants and funding

The work is supported by a grant from the Health and Medical Research Fund of the Food and Health Bureau of the Hong Kong Special Administrative Region Government (HMRF 15140862).