Abstract
The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.
Keywords:
bifunctionals; chloroethylethylsulfide; inflammation; phorbol ester; skin; sulfur mustard; vesicants.
© 2016 New York Academy of Sciences.
Publication types
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Review
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Anti-Inflammatory Agents / administration & dosage*
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Anti-Inflammatory Agents / metabolism
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Chemical Warfare Agents / metabolism
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Chemical Warfare Agents / toxicity*
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Cholinesterase Inhibitors / administration & dosage
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Cholinesterase Inhibitors / metabolism
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Cyclooxygenase Inhibitors / administration & dosage
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Cyclooxygenase Inhibitors / metabolism
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Drug Delivery Systems / methods*
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Drug Delivery Systems / trends
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Drug Discovery / trends
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Humans
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Mustard Gas / metabolism
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Mustard Gas / toxicity*
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Prodrugs / administration & dosage*
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Prodrugs / metabolism
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Skin / drug effects*
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Skin / injuries
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Skin / metabolism
Substances
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Anti-Inflammatory Agents
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Chemical Warfare Agents
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Cholinesterase Inhibitors
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Cyclooxygenase Inhibitors
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Prodrugs
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Mustard Gas