Reciprocal Regulation of 11β-HSDs May Predict Steroid Sensitivity in Childhood Nephrotic Syndrome

Shuji Sai; Masaki Yamamoto; Rie Yamaguchi; Karen E Chapman; Teruaki Hongo

doi:10.1542/peds.2015-4011

Reciprocal Regulation of 11β-HSDs May Predict Steroid Sensitivity in Childhood Nephrotic Syndrome

Pediatrics. 2016 Sep;138(3):e20154011. doi: 10.1542/peds.2015-4011. Epub 2016 Aug 9.

Authors

Shuji Sai¹, Masaki Yamamoto², Rie Yamaguchi³, Karen E Chapman⁴, Teruaki Hongo⁵

Affiliations

¹ Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan; Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland; [email protected].
² Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Pediatrics, Seirei Hamamatsu General Hospital, Hamamatsu, Japan; and.
³ Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan;
⁴ Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland;
⁵ Department of Pediatrics, Iwata City Hospital; Iwata, Japan.

PMID: 27507896
DOI: 10.1542/peds.2015-4011

Abstract

Childhood nephrotic syndrome, in which steroid-dependence occurs concurrently with steroid-resistance, requires aggressive therapy to prevent relapse. Predictive biomarkers that can be used to stratify treatment are urgently needed. Here we report that reciprocal regulation of the glucocorticoid metabolizing enzymes, 11β-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-responsiveness and disease remission in childhood nephrotic syndrome, potentially providing a marker to identify patients in which aggressive therapy is required.

MeSH terms

11-beta-Hydroxysteroid Dehydrogenase Type 1 / blood*
11-beta-Hydroxysteroid Dehydrogenase Type 2 / blood*
Adolescent
Anti-Inflammatory Agents / therapeutic use*
Biomarkers / blood
Child
Child, Preschool
Dexamethasone / therapeutic use
Drug Administration Schedule
Drug Resistance*
Drug Tolerance*
Female
Humans
Induction Chemotherapy
Maintenance Chemotherapy
Male
Nephrotic Syndrome / blood
Nephrotic Syndrome / diagnosis
Nephrotic Syndrome / drug therapy*
Nephrotic Syndrome / enzymology
Prednisolone / therapeutic use*
Receptors, Glucocorticoid / blood
Recurrence
Treatment Outcome

Substances

Anti-Inflammatory Agents
Biomarkers
NR3C1 protein, human
Receptors, Glucocorticoid
Dexamethasone
Prednisolone
11-beta-Hydroxysteroid Dehydrogenase Type 1
11-beta-Hydroxysteroid Dehydrogenase Type 2
HSD11B1 protein, human
HSD11B2 protein, human