Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis

J F Dowsett; T Gillow; A Heagerty; M Radcliffe; R Toadi; I Isle; R C Russell

doi:10.1007/BF01537281

Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis

Dig Dis Sci. 1989 Aug;34(8):1290-3. doi: 10.1007/BF01537281.

Authors

J F Dowsett¹, T Gillow, A Heagerty, M Radcliffe, R Toadi, I Isle, R C Russell

Affiliation

¹ Department of Gastroenterology, University College and Middlesex Hospital, Medical School, U.K.

PMID: 2752877
DOI: 10.1007/BF01537281

Abstract

A 75-year-old man developed a biopsy-proven, drug-induced intrahepatic cholestasis after use of amoxycillin trihydrate combined with the beta-lactam inhibitor potassium clavulanate (Augmentin). Cholestatic liver injury is an uncommonly recognized, probably immunologically based adverse reaction to therapy with penicillin and its derivatives.

Publication types

Case Reports

MeSH terms

Aged
Amoxicillin / adverse effects*
Amoxicillin-Potassium Clavulanate Combination
Cholestasis, Intrahepatic / chemically induced*
Cholestasis, Intrahepatic / pathology
Clavulanic Acids / adverse effects*
Drug Therapy, Combination / adverse effects
Humans
Liver / pathology
Male

Substances

Clavulanic Acids
Amoxicillin-Potassium Clavulanate Combination
Amoxicillin