Vestaines, novel vasoactive compounds, isolated from Streptomyces sp. SANK 63697

Yuki Hirota-Takahata; Emi Kurosawa; Yoko Ishimoto; Yuko Iwadate; Masaaki Kizuka; Jun Chiba; Toru Hasegawa; Masahiro Tanaka; Hideki Kobayashi

doi:10.1038/ja.2016.98

Vestaines, novel vasoactive compounds, isolated from Streptomyces sp. SANK 63697

J Antibiot (Tokyo). 2017 Feb;70(2):179-186. doi: 10.1038/ja.2016.98. Epub 2016 Aug 17.

Authors

Yuki Hirota-Takahata¹, Emi Kurosawa¹, Yoko Ishimoto², Yuko Iwadate¹, Masaaki Kizuka¹, Jun Chiba³, Toru Hasegawa⁴, Masahiro Tanaka¹, Hideki Kobayashi²

Affiliations

¹ Discovery Science and Technology Department, Daiichi Sankyo RD Novare, Tokyo, Japan.
² Frontier Research Laboratories, Daiichi Sankyo, Tokyo, Japan.
³ Medicinal Chemistry Research Laboratories, Daiichi Sankyo, Tokyo, Japan.
⁴ Organic Synthesis Department, Daiichi Sankyo RD Novare, Tokyo, Japan.

PMID: 27531222
DOI: 10.1038/ja.2016.98

Abstract

We conducted a screening program for vasoactive compounds and detected a potent activity in the cultured broth of Streptomyces sp. SANK 63697. From the cultured broth, two active compounds, vestaine A₁ and B₁, were isolated. The structures of these compounds were elucidated by physicochemical data and spectral analyses, and found to be new compounds.

MeSH terms

Acetylcysteine / analogs & derivatives*
Acetylcysteine / chemistry
Acetylcysteine / metabolism
Acetylcysteine / pharmacology
Cardiovascular Agents / chemistry
Cardiovascular Agents / metabolism
Cardiovascular Agents / pharmacology
Coculture Techniques
Endothelial Cells / drug effects
Fibroblasts / drug effects
Humans
Molecular Structure
Quaternary Ammonium Compounds / chemistry
Quaternary Ammonium Compounds / metabolism*
Quaternary Ammonium Compounds / pharmacology
Streptomyces / metabolism*

Substances

Cardiovascular Agents
Quaternary Ammonium Compounds
vestaine A1
vestaine B1
Acetylcysteine