Abstract
FOXC1 is a member of Forkhead box family transcription factors. We showed that FOXC1 level was increased in melanoma cells and tissues and correlated with hypomethylation of the FOXC1 gene. Overexpression of FOXC1 promoted proliferation, migration, invasion, colony formation and growth in 3D Matrigel of melanoma cells. FOXC1 increased MST1R and activated the PI3K/AKT pathway. Also, FOXC1 expression was associated with disease progression and poor prognosis of melanoma. We suggest that FOXC1 is a potential prognostic biomarker for treating melanoma and predicting outcome of patients.
Keywords:
FOXC1; MST1R/PI3K/AKT pathway; cutaneous melanoma; methylation.
MeSH terms
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Movement / drug effects
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Cell Movement / genetics
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Cell Proliferation / drug effects
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Cell Proliferation / genetics
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Forkhead Transcription Factors / genetics*
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Forkhead Transcription Factors / metabolism
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Gene Expression Regulation, Neoplastic / drug effects
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Humans
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Indoles / pharmacology
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Melanoma / genetics*
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Melanoma / metabolism
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Melanoma / pathology
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Phosphatidylinositol 3-Kinases / metabolism
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Prognosis
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Proto-Oncogene Proteins c-akt / metabolism
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RNA Interference
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Receptor Protein-Tyrosine Kinases / genetics*
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Receptor Protein-Tyrosine Kinases / metabolism
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Signal Transduction / drug effects
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Signal Transduction / genetics
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Skin Neoplasms / genetics*
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Skin Neoplasms / metabolism
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Skin Neoplasms / pathology
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Sulfonamides / pharmacology
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Vemurafenib
Substances
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Antineoplastic Agents
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FOXC1 protein, human
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Forkhead Transcription Factors
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Indoles
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Sulfonamides
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Vemurafenib
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Phosphatidylinositol 3-Kinases
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RON protein
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Receptor Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-akt