Abstract
Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal, Villaescusa et al (2016) show the transcription factor Pbx1 is required for the differentiation and survival of midbrain dopaminergic neurons. Notably, Pbx1 protects from oxidative stress by inducing Nfe2l1, and the expression of both genes is reduced in dopaminergic neurons from Parkinson's patients. This is an important study, with possible implications in regenerative medicine and drug design.
MeSH terms
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Cell Differentiation
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Cell Survival
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DNA-Binding Proteins
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Dopamine
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Dopaminergic Neurons*
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Mesencephalon*
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Neurons
Substances
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DNA-Binding Proteins
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Dopamine