Abstract
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) has been found on human memory T lymphocytes. However, the roles of KLRG1 on human T cells especially in tumor microenvironment have not been fully understood. Our results showed KLRG1 expression on T cells significantly increased in tumor microenvironment. KLRG1+ T cells exhibited poor proliferative capacity with decreased effector cytokine production. Meanwhile, KLRG1+ T cells expressed abundant pro-inflammatory cytokines and demonstrated high level of Foxp3 expression. KLRG1+ T cells showed decreased expression of miRNA-101 and higher expression of CtBP2. Our results indicated KLRG1 might contribute to the impaired antitumor immunity of memory T cells in tumor microenvironment. Thus, repressing KLRG1 on human memory T cells might be a novel therapeutics against cancer.
Keywords:
KLRG1; antitumor immunity; memory T cells; senescence.
MeSH terms
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Alcohol Oxidoreductases / metabolism
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Cell Line, Tumor
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Cell Proliferation
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Cell Separation
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Cellular Senescence
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Co-Repressor Proteins
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Cytokines / metabolism
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Flow Cytometry
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Forkhead Transcription Factors / metabolism
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Humans
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Immunologic Memory*
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Immunophenotyping
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Killer Cells, Natural / immunology
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Lectins, C-Type / metabolism*
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Leukocytes, Mononuclear / metabolism
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MicroRNAs / metabolism
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Neoplasms / immunology*
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Neoplasms / therapy
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Nerve Tissue Proteins / metabolism
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Receptors, Immunologic
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Signal Transduction
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
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Trans-Activators / metabolism*
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Tumor Microenvironment
Substances
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Co-Repressor Proteins
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Cytokines
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FOXP3 protein, human
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Forkhead Transcription Factors
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KLRG1 protein, human
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Lectins, C-Type
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MIRN101 microRNA, human
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MicroRNAs
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Nerve Tissue Proteins
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Receptors, Immunologic
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Trans-Activators
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Alcohol Oxidoreductases
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CTBP2 protein, human