Harmful effect of epinephrine on postreperfusion syndrome in an elderly liver transplantation recipient with sigmoid ventricular septum: A case report

Medicine (Baltimore). 2016 Aug;95(34):e4394. doi: 10.1097/MD.0000000000004394.

Abstract

Introduction: As a common morphological change of aging heart, sigmoid ventricular septum is frequently found during routine preoperative evaluation, but often disregarded because of its little clinical importance. However, in this report, we describe a 70-year old patient with sigmoid ventricular septum who developed severe hemodynamic deterioration during liver transplantation because of its unique morphology of heart.

Methods: During the course of reperfusion of the graft, patient's hemodynamics were closely monitored using transesophageal echocardiography.

Results: Immediately after graft reperfusion, epinephrine was given as a treatment of choice for postreperfusion syndrome. Surprisingly, however, hemodynamic derangement persisted and became even worse. Intraoperative transesophageal echocardiography revealed left ventricular outflow tract obstruction resulting from systolic anterior motion of the mitral valve leaflet. Therefore, the patient was treated with phenylephrine and fluid bolus under the guidance of transesophageal echocardiography.

Conclusion: As more elderly recipient present for liver transplantation surgery nowadays, left ventricular outflow tract obstruction should always be considered as a possible cause for hemodynamic instability during reperfusion period. In addition, transesophageal echocardiography is a useful tool for both diagnosis of hemodynamic derangement and guidance for appropriate management during liver transplantation surgery.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Echocardiography
  • Epinephrine / adverse effects*
  • Fluid Therapy
  • Heart Septum / diagnostic imaging
  • Heart Ventricles / diagnostic imaging
  • Hemodynamics / drug effects
  • Humans
  • Intraoperative Complications / diagnostic imaging
  • Intraoperative Complications / etiology*
  • Intraoperative Complications / therapy
  • Liver Transplantation / adverse effects
  • Male
  • Phenylephrine / therapeutic use
  • Reperfusion / adverse effects*
  • Syndrome
  • Vasoconstrictor Agents / adverse effects*
  • Vasoconstrictor Agents / therapeutic use
  • Ventricular Outflow Obstruction / diagnostic imaging
  • Ventricular Outflow Obstruction / etiology*
  • Ventricular Outflow Obstruction / therapy

Substances

  • Vasoconstrictor Agents
  • Phenylephrine
  • Epinephrine