Abstract
Eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from Agrimonia pilosa along with six other known compounds (9-14). The new compounds were characterized structurally by NMR, MS, and ECD analyses. Compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from Nature. The absolute configuration of compound 8 was elucidated by computational analysis of its ECD spectrum. The isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced NO production in BV2 microglial cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agrimonia / chemistry*
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Animals
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Biflavonoids
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Catechin / chemistry
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Catechin / isolation & purification*
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Catechin / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Isocoumarins / chemistry
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Isocoumarins / isolation & purification*
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Isocoumarins / pharmacology
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis
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Nuclear Magnetic Resonance, Biomolecular
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Phloroglucinol / analogs & derivatives*
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Phloroglucinol / chemistry
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Phloroglucinol / isolation & purification
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Proanthocyanidins
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Republic of Korea
Substances
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Biflavonoids
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Drugs, Chinese Herbal
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Glycosides
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Isocoumarins
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Lipopolysaccharides
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Proanthocyanidins
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Nitric Oxide
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procyanidin
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Catechin
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Phloroglucinol