Abstract
We compared bioavailability of 4-methyl-2,6-diisobornylphenol after single intragastric administration to rats in a dose of 200 mg/kg in starch suspension and in almond oil. Absorption of 4-methyl-2,6-diisobornylphenol in the gastrointestinal tract after administration in almond oil was much more efficient than after administration in aqueous starch mucus.
Keywords:
4-methyl-2,6-diisobornylphenol; absorption; bioavailability.
MeSH terms
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Administration, Oral
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Animals
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Antioxidants / administration & dosage*
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Antioxidants / pharmacokinetics*
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Camphanes / administration & dosage*
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Camphanes / pharmacokinetics*
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Cresols / administration & dosage*
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Cresols / pharmacokinetics*
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Gastrointestinal Tract / metabolism
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Intestinal Absorption / drug effects
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Male
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Phenols / administration & dosage*
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Phenols / pharmacokinetics*
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Plant Oils / chemistry
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Rats
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Rats, Wistar
Substances
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4-methyl-2,6-diisobornylphenol
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Antioxidants
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Camphanes
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Cresols
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Phenols
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Plant Oils
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almond oil