A Gold(I)-Catalyzed Domino Coupling of Alcohols with Allenes Enables the Synthesis of Highly Substituted Indenes

Alexander Preinfalk; Antonio Misale; Nuno Maulide

doi:10.1002/chem.201603154

A Gold(I)-Catalyzed Domino Coupling of Alcohols with Allenes Enables the Synthesis of Highly Substituted Indenes

Chemistry. 2016 Oct 4;22(41):14471-4. doi: 10.1002/chem.201603154. Epub 2016 Sep 6.

Authors

Alexander Preinfalk¹, Antonio Misale¹, Nuno Maulide²

Affiliations

¹ Faculty of Chemistry, Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
² Faculty of Chemistry, Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria. [email protected].

PMID: 27596096
DOI: 10.1002/chem.201603154

Abstract

The reaction of aryl-substituted allenes with alcohols under gold catalysis led to highly substituted indenes in good yields, with low catalyst loading and under mild conditions. During this domino transformation, two C-C bonds are formed with water as the only byproduct.

Keywords: alcohols; allenes; domino coupling; gold catalysis; indenes.